Dual functions of Insig proteins in cholesterol homeostasis
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چکیده
منابع مشابه
Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.
Insig-1 and Insig-2 are closely related proteins of the endoplasmic reticulum (ER) that mediate feedback control of cholesterol synthesis by sterol-dependent binding to the following two membrane proteins: the escort protein Scap, thus preventing proteolytic processing of sterol regulatory element-binding proteins; and the cholesterol biosynthetic enzyme 3-hydroxy-3-methylglutaryl CoA reductase...
متن کاملSchoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
End-product feedback inhibition of cholesterol synthesis was first demonstrated in living animals by Schoenheimer 72 years ago. Current studies define Insig proteins as essential elements of this feedback system in mouse liver. In cultured cells, Insig proteins are required for sterol-mediated inhibition of the processing of sterol regulatory element-binding proteins (SREBPs) to their nuclear f...
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Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR; cholesterol-lowering)- and sterol regulatory element-binding protein (SREBP; cholesterol-raising)-mediated signaling pathways. Previously we reported that the hypocholesterolemic agent LY295427 (4alpha-allylcholestan-3alpha-ol) reverses oxysterol-mediated suppression of SREBP processing. We now report that LY295427 incre...
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Journal of Lipid Research Volume 53, 2012 1359 Copyright © 2012 by the American Society for Biochemistry and Molecular Biology, Inc. unusual in that they have three, rather than two, sources of cholesterol. Enterocytes uniquely absorb free cholesterol from the gut lumen, and they also share two ubiquitous sources with other cells: endogenous synthesis of sterols de novo and uptake of LDL-derive...
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ژورنال
عنوان ژورنال: Lipids in Health and Disease
سال: 2012
ISSN: 1476-511X
DOI: 10.1186/1476-511x-11-173